RESUMO
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Assuntos
Humanos , Glucuronidase/sangue , Doenças da Glândula Tireoide/diagnóstico , Biomarcadores/análise , ColorimetriaRESUMO
Objetivos: Investigar la concentración y actividad de la antitrombina III en cuarenta sujetos (20 controles sano y 20 con hepatitis aguda A y B). Material y métodos: Estudio prospectivo de 40 sujetos (de edad 36 +/- 12 años). 20 sujetos sanos y 20 pacientes con hepatitis aguda. La antitrombina se determinó por inmunodifusión radial (concentración) y sustratos cromogénicos (actividad). Resultados.- La concentración ya actividad plasmáticas de antitrombina III estuvo significativamente aumentada en la hepatitis aguda comparada con los sujetos santos, con significación estadística. Conclusión. La antitrombina III (antigénica y actividad) presentó niveles elevados en las hepatitis agudas frente a los sujetos sanos como expresión del fenómeno de la reacción proteica aguda
Aims.- concentration and activity of antitrombin are investigated in forty subjects. Matherial and methods.- Prospective study of 40 subjects (aged 36+/- 12 years). Twenty healthy subjects and twenty patients with acute hepatitis. Antithrombin III were determined by radial inmunodifusion (Mancini) concentration- and cromogenic substrate activity - . Results.- Plasma antithrombin III concentration and activity antithrombin III heparina cofactor by significantly increased in acute hepatitis compared with healthy subjects with statistical significance. Conclusion.- The antithrombin III (antigen and activity) present higher level in acute hepatitis than in healthy subjects like expression of a phenomenon of acute protein reaction (AU)
Assuntos
Humanos , Antitrombina III/análise , Hepatite Viral Humana/fisiopatologia , Estudos de Casos e Controles , Estudos ProspectivosRESUMO
Antithrombin III (AT III) levels in 37 healthy people and in 103 patients diagnosed of hepatic cirrhosis (75 due to ethylism, 26 cryptogenic and 7 post-hepatitis) have been studied. Forty seven patients presented a compensation in their cirrhosis and 56 an unbalance. AT III concentration was decreased in cirrhotic patients (14.9 + 1.09 mg/dl), being p less than 0.0005 in relation to healthy patients (24.3 + 0.87 mg/dl). Concentration resulted lesser in patients with unbalance (13.9 + 1.8 mg/dl) than in patients with compensation (18.1 + 1.6 mg/dl). Moreover, statistical study between them showed significant results. AT III, though is a protein whose hepatic synthesis is not clear, decreases in diffuse hepatic disease and so much as more severe is the hepatic damage. Cirrhotic patients did not present thromboembolic phenomena, perhaps because of depression of coagulation factors.
